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Fig. 9 | Breast Cancer Research

Fig. 9

From: TMEM120B strengthens breast cancer cell stemness and accelerates chemotherapy resistance via β1-integrin/FAK-TAZ-mTOR signaling axis by binding to MYH9

Fig. 9

TMEM120 expression positively correlated with TAZ, p-mTOR, SOX2, and chemotherapy resistance in breast cancer specimens. (A) Representative images of immunohistochemistry staining of TMEM120B, phosphorylated mTOR, and TAZ in human breast cancer specimens. (B) Representative images of immunohistochemistry staining of TMEM120B and SOX2 human breast cancer specimens. (C) Representative images of immunohistochemistry staining of TMEM120B in specimens from breast cancer patients with varying therapeutic effects evaluated using Miller/Payne Grades after neoadjuvant chemotherapy. (D) Pathway diagram for TMEM120B functional activity interaction with MYH9 in breast cancer cells. Quantification data are expressed as mean ± SD of three independent experiments (t-test, two-sided, ***, P < 0.001)

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Breast Cancer Research

ISSN: 1465-542X

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