Fig. 5
The correlation between UCHL1 and the expression of genes encoding DNA methyltransferases and demethylases. (A) A heatmap showing the correlation among the expression of UCHL1, DNA methyltransferase genes (DNMT1, DNMT3A and DNMT3B) as well as demethylase genes (TET1, TET2, and TET3) in the primary tumor samples in TCGA-BRAC. (B) Correlation analysis between the methylation levels of 7 CpGs in the UCHL1 promoter region and the expression levels of DNA methyltransferase genes (DNMT1, DNMT3A, and DNMT3B) as well as demethylase genes (TET1, TET2, and TET3). (C) Comparison of TET1, TET2 and TET3 expression in normal breast tissue (GTEx-B), TCGA breast cancer (TCGA-BRCA) subtypes, and adjacent cancer tissues (T adj.). **, pā<ā0.01; ***, pā<ā0.001