Fig. 3

UCHL1 negatively regulates ERα expression and the responses to endocrine therapy via KLF5 in TNBC in vivo. 5-week-old female nude mice were inoculated s.c. with MDA-MB-468 TNBC cells with indicated lentivirus infections. The tumor-bearing mice then received indicated treatment. The tumor sizes were measured on the days as indicated. (A) Subcutaneous tumors were excised, and photographs were taken at the termination of the experiment. (B) Tumor weight was measured after removal. Data represents the mean ± SD of tumor sizes of each group (n = 5 or 6). C-D. Immunohistochemistry staining for Ki-67 (C) and ERα (D) in the tumor specimens from the mice. *, p < 0.05; **, p < 0.01; ***, p < 0.001