Fig. 3

TNBC cells have different metastatic potentials to the liver A Representative tissue sections stained with H&E, obtained from livers of mice 9 weeks after injection of TNBC cells in their 4th left mammary gland. Scale bar is 1 mm; inset scale bar is 500 μm dashed lines represent metastasis boundary, black arrows identify smaller metastases. B Number of mice that developed liver metastases for each cell line. C The number of metastases per liver for each cell line and D Metastatic burden in the liver (ratio of the number of metastases in the lungs to the primary tumor volume) E Average size of each liver metastasis. Data are shown as mean with SEM 231 n = 9, 468 n = 10, BT549 n = 10, BT20 n = 9, SUM159 n = 10, Hs578T n = 10 animals/group. Significance was determined using a one-way ANOVA with Tukey’s multiple comparison test comparing each cell line to every other cell line. Significance (p < 0.05) is denoted by a letter corresponding to each cell line tested, 231 (a), 468 (b), BT549 (c), BT20 (d), SUM159 (e), Hs578T (f)