Fig. 6
From: The FBXW7-binding sites on FAM83D are potential targets for cancer therapy
FAM83D expression negatively correlates with FBXW7 expression in BC tissues and positively associated with poor prognosis of patients with BC. a, Representative images of IHC staining for FAM83D and FBXW7 protein in paired breast cancer (BC) tissues and the non-cancerous tissues. b, Representative images of IHC staining for FAM83D and FBXW7 protein in BC tissues. c, The correlation between the expression of USP35 FAM83D and FBXW7 in BC tissues (n = 40). d, The box plot indicated the relative FBXW7 level in FAM83D-low and FAM83D-high patients (Median FAM83D or FVXW7 expression was defined as cut-off point). e-g, Significant association of FAM83D expression with overall survival (OS) (e), disease-free survival (DFS) (f), and distant metastasis-free survival (DMFS) (g). The Kaplan-Meier curves were generated using Breast Cancer Gene-Expression Miner v5.0. h-j, The forest plot shows the association of FAM83D expression with overall OS (h), DFS (i), and DMFS (j) in different ER status and PAM50 molecular subtypes. All p-values were obtained from the log-rank test