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Table 2 AI-analyzed intratumoral image patch proportions and PDX engraftment success in primary breast cancers

From: Factors associated with engraftment success of patient-derived xenografts of breast cancer

Variable *

All (n = 353)

NAC group (n = 131)

Failure (n = 294)

Success (n = 59)

p-value**

Failure (n = 93)

Success (n = 38)

p-value**

AP

639.9 ± 727.1

409.0 ± 484.0

0.006

517.3 ± 622.2

450.9 ± 528.0

0.564

NP

740.7 ± 981.9

1575.0 ± 1264.1

 < 0.001

901.3 ± 1101.4

1642.8 ± 1358.9

0.001

TDLUP

504.4 ± 692.5

219.8 ± 233.3

 < 0.001

475.2 ± 730.2

201.6 ± 213.9

0.001

SP

3377.5 ± 1265.9

2855.3 ± 1094.8

0.007

3512.4 ± 1523.4

2855.7 ± 1180.3

0.019

TILP

17.8 ± 22.8

15.0 ± 15.9

0.285

10.2 ± 14.0

11.3 ± 13.3

0.678

ICP

4208.0 ± 1450.8

4571.6 ± 1201.5

0.096

3056.0 ± 1470.1

3271.5 ± 1174.1

0.423

  1. AP Adipose proportion, NP Necrosis proportion, BP Background proportion, TDLUP Terminal ductal lobular unit proportion, SP Stroma proportion, TILP Tumor-infiltrating lymphocyte proportion, ICP Invasive carcinoma proportion;
  2. *Values scaled up by 10,000
  3. **Bold: significant at p-value < 0.05