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Fig. 1 | Breast Cancer Research

Fig. 1

From: Small molecule inhibitor targeting the Hsp70-Bim protein–protein interaction in estrogen receptor-positive breast cancer overcomes tamoxifen resistance

Fig. 1

S1g-2 is more effective in tamoxifen-resistant breast cancer cell lines than their sensitive counterparts A IC50 values for VER-155008, MKT-077, and S1g-2 at 48 h in MCF-7, MCF-7/TAM-R, T47D and T47D/TAM-R cells, determined by the CCK-8 assay. The data are expressed as mean ± SD (n = 3 biologically independent experiments) *P < 0.05, **P < 0.01 (one-way ANOVA test); n.s. indicates no significance. B Combination index (CI) values of, tamoxifen/VER-155008, tamoxifen/MKT-077, and tamoxifen/S1g-2 combination respectively in MCF-7, MCF-7/TAM-R, T47D and T47D/TAM-R cells

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Breast Cancer Research

ISSN: 1465-542X

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