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Table 2 Demographic data for patients with at least one month between the CNS metastatic disease diagnosis and the BC-LMD diagnosis

From: Factors associated with overall survival in breast cancer patients with leptomeningeal disease (LMD): a single institutional retrospective review

 

Total

HR + 

HER2 + 

TNBC

Number of patients

48

19

19

10

Median age at CNS metastasis

50.5 [26, 81]

51 [38, 68]

52 [32, 81]

47.5 [26, 66]

Median age at LMD diagnosis

51.5 [27, 82]

52 [39, 70]

53 [37, 82]

48 [27, 68]

Race

 Black

3 (6%)

1 (5.3%)

1 (5.3%)

1 (10%)

 Other

5 (10%)

3 (16%)

2 (11%)

0 (0%)

 White

40 (83%)

15 (79%)

16 (84%)

9 (90%)

Stage at diagnosis

 <=2

17 (35%)

6 (32%)

6 (35%)

5 (50%)

 =>3

29 (60%)

13 (68%)

11 (65%)

5 (50%)

MRI only confirmed LMD diagnosis

28 (58%)

14 (74%)

10 (53%)

4 (40%)

MRI + CSF confirmed LMD diagnosis

20 (42%)

5 (26%)

8 (42%)

6 (60%)

  1. BC Breast Cancer; HR + Hormone Receptor Positive; HER2 + Human Epidermal Growth Factor Receptor 2-Positive; TNBC Triple Negative Breast Cancer; CNS Central Nervous System; LMD Leptomeningeal Disease; MRI Magnetic Resonance Imagining; CSF Cerebrospinal Fluid