Skip to main content

Table 1 Demographic data for all patients diagnosed with BC-LMD at Moffitt Cancer Center between 2011 and 2020

From: Factors associated with overall survival in breast cancer patients with leptomeningeal disease (LMD): a single institutional retrospective review

 

Total

HR + 

HER2 + 

TNBC

Number of patients

128

66

34

28

Median age at BC diagnosis

51 [22, 79]

55 [25, 76]

50.5 [22, 79]

45.5 [24, 69]

Median age at CNS metastasis

53 [26, 81]

55 [38, 68]

52 [32, 81]

47 [26, 66]

Median age at LMD diagnosis

54 [27, 83]

58.5 [27, 79]

53.5 [29, 83]

48 [27, 70]

Race

 Black

12 (9.3%)

7 (11%)

1 (2.9%)

4 (14%)

 Other

21 (16%)

10 (15%)

6 (18%)

5 (18%)

 White

95 (74%)

49 (74%)

27 (79%)

19 (68%)

Stage at BC diagnosis

 <=2

43 (34%)

21 (32%)

10 (29%)

12 (43%)

 =>3

77 (60%)

41 (62%)

22 (65%)

14 (50%)

Systemic metastasis

100 (78%)

57 (86%)

27 (79%)

16 (57%)

CNS metastasis

114 (89%)

56 (85%)

31 (91%)

27 (96%)

MRI only confirmed LMD diagnosis

70 (55%)

40 (61%)

19 (56%)

11 (39%)

MRI + CSF confirmed LMD diagnosis

54 (42%)

25 (38%)

14 (41%)

15 (54%)

  1. BC Breast Cancer; HR + Hormone Receptor Positive; HER2 + Human Epidermal Growth Factor Receptor 2-Positive; TNBC Triple Negative Breast Cancer; CNS Central Nervous System; LMD Leptomeningeal Disease; MRI Magnetic Resonance Imagining; CSF Cerebrospinal Fluid