Fig. 4

Kaplan Meier analysis of BC-LMD patients receiving different combinations of WBRT, Systemic Therapy, and/or IT therapy. Patients receiving only IT, systemic + IT, WBRT + IT, WBRT + systemic therapy, or all three therapies had a significantly longer median OS than patients that received no therapy (p < 0.05, respectively). Compared to WBRT alone, patients receiving WBRT + systemic therapy or WBRT + systemic therapy + IT therapy had a significantly longer median OS (p < 0.0001, respectively). BC-LMD Breast Cancer Leptomeningeal Disease; OS Overall Survival; IT Intrathecal Therapy; WBRT Whole Brain Radiation Therapy