Fig. 6

Increased glycolysis correlates with NAC resistance in patient-derived TNBC clinical specimens. A Schematic representation of the clinical workflow for collection of diagnostic biopsies from patients with early-stage TNBC treated with NAC, recruited in this study. B RNA-sequencing datasets, from early TNBC human patients, used for gene set enrichment analysis (GSEA) between responders (RCB 0/I) and non-responders (RCB II/III) to NAC. C–F Pathways significantly up- and down-regulated (C, E) and individual enrichment plots for glycolysis hallmark (D, F) from GSEA of RNA-seq data in NAC-responding and non-responding TNBC specimens (GSE240671 and GSE123845 datasets for C, D and E, F panels, respectively)