Table 2 Clinicopathologic characteristics according to sTIL density (< 10% versus ≥ 10%) in TNBC
From: HER2-low and tumor infiltrating lymphocytes in triple-negative breast cancer: Are they connected?
Tumor characteristics | TILs < 10% (n = 368) | TILs ≥ 10% (n = 458) | Univariable |
|---|---|---|---|
P value | |||
Age (n = 826) | |||
< 50 | 63 (17.1) | 148 (32.3) | < 0.001 |
≥ 50 | 305 (82.9) | 310 (67.7) | |
Missing | 0 | 0 | |
Histologic type (n = 822) | |||
NST | 312 (85.5) | 426 (93.2) |  < 0.001 |
Lobular | 21 (5.8) | 10 (2.2) | |
Other | 32 (8.8) | 21 (4.6) | |
Missing | 3 | 1 | |
Grade of invasive component (n = 755) | |||
1 | 27 (8.3) | 7 (1.6) | < 0.001 |
2 | 161 (49.4) | 171 (39.9) | |
3 | 138 (42.3) | 251 (58.5) | |
Missing | 42 | 29 | |
Angioinvasion (n = 609) | |||
Yes | 18 (7) | 22 (6.3) | 0.727 |
Uncertain | 4 (1.6) | 5 (1.4) | |
No | 236 (91.5) | 324 (92.3) | |
Missing | 110 | 107 | |
Mitosis (n = 140) | |||
< 8 | 30 (44.8) | 19 (26) | 0.02 |
≥ 8 | 37 (55.2) | 54 (74) | |
Missing | 301 | 405 | |
Ki67 (n = 90) | |||
< 40 | 12 (33.3) | 11 (20.4) | 0.167 |
≥ 40 | 24 (66.7) | 43 (79.7) | |
Missing | 36 | 54 | |
Axillary nodal status (n = 678) | |||
Negative | 183 (64.4) | 217 (55.1) | 0.014 |
Positive | 101 (35.6) | 177 (44.9) | |
Unknown | 84 | 64 | |
HER2 status (n = 820) | |||
HER2 0 | 238 (65.2) | 288 (63.3) | 0.571 |
HER2 low | 127 (34.8) | 167 (36.7) | |
Missing | 3 | 3 | |