Table 1 Clinicopathologic characteristics according to HER2 status (HER2-0 vs. HER2-low) in TNBC
From: HER2-low and tumor infiltrating lymphocytes in triple-negative breast cancer: Are they connected?
Tumor characteristics | HER2-0 (n = 527) | HER2-low (n = 294) | P value |
|---|---|---|---|
Age (n = 821) | |||
< 50 | 136 (25.8) | 74 (25.2) | 0.841 |
≥ 50 | 391 (74.2) | 220 (74.8) | |
Missing | 0 | 0 | |
Surgery (n = 614) | |||
Mastectomy | 165 (42.4) | 112 (49.8) | 0.077 |
Lumpectomy | 224 (57.6) | 113 (50.2) | |
Missing | 138 | 69 | |
Histologic type (n = 818) | |||
No special type | 474 (90.3) | 260 (88.7) | < 0.001 |
Lobular | 9 (1.7) | 22 (7.5) | |
Other | 42 (8) | 11 (3.8) | |
Missing | 2 | 1 | |
Grade of invasive component = 752 | |||
1 | 12 (2.5) | 21 (7.8) | < 0.001 |
2 | 207 (42.9) | 125 (46.5) | |
3 | 264 (54.7) | 123 (45.7) | |
Missing | 44 | 25 | |
Angioinvasion (n = 604) | |||
Yes | 23 (6.1) | 17 (7.6) | 0.381 |
Uncertain | 4 (1.1) | 5 (2.2) | |
No | 353 (92.9) | 202 (90.2) | |
Missing | 147 | 70 | |
Mitosis (n = 136) | |||
< 8 | 32 (35.6) | 16 (34.8) | 0.929 |
≥ 8 | 58 (64.4) | 30 (65.2) | |
Missing | 437 | 248 | |
Ki67 (n = 87) | |||
< 40 | 8 (14.5) | 15 (46.9) | < 0.001 |
≥ 40 | 47 (85.5) | 17 (53.1) | |
Missing | 472 | 262 | |
sTILs (median, range) | 10 (5–20) | 10 (5–26) | 0.476 |
Missing | 1 | 0 | |
sTILS (n = 820) | |||
< 10% | 238 (45.2) | 127 (43.2) | 0.571 |
≥ 10% | 288 (54.8) | 167 (56.8) | |
Missing | 1 | 0 | |
Axillary nodal status (n = 672) | |||
Negative | 273 (63.9) | 123 (50.2) | < 0.001 |
Positive | 154 (36.1) | 122 (49.8) | |
Unknown | 100 | 49 | |