A phase 1b study of zilovertamab in combination with paclitaxel for locally advanced/unresectable or metastatic HER2-negative breast cancer

Table 1 Patient demographics

BROR#	Age at enroll	Stage at DX	ER at DX	PR at DX	ER at enroll	PR at enroll	Time from DX to 1st met (months)	Disease sites at enrollment	Prior therapies for mets
01*	54	T3N3M0	99% 3+	40% 3+	99% 3+	99% 3+	23	Bone, liver	3-Endo, 3-Chemo
02*	59	T2N2M0	Positive	Positive	Negative	Negative	152	Bone, chest wall, non-regional lymph nodes	1-Endo, 0-Chemo
03	42	T2N1M0	80% 2+	10% 2+	Negative	Negative	34	Bone, chest wall	3-Endo, 3-Chemo
05	41	T2N0M0	Negative	Negative	Negative	Negative	32	Chest wall, lung	1-Endo, 3-Chemo
07*	42	T4N1M0	Positive	Positive	5% 1+	40% 1+	56	Bone, liver, lung	4-Endo, 3-Chemo
08*	59	T1N1M0	50% 2+	50% 2+	25% 2+	40% 2+	77	Bone, lung, retroperitoneal mass	1-Endo, 2-Chemo
09	30	T3N1M0	0%	0%	Negative	Negative	22	Lung	0-Endo, 0-Chemo
11	72	T2N1MO	30% 1+	30% 1+	5% 2+	85% 1+	27	Chest wall	0-Endo, 0-Chemo
12	54	T2NOMO	6%	0%	Negative	Negative	17	Lung	0-Endo, 0-Chemo
13*	69	T1N0M0	Positive	Positive	95% 3+	20% 3+	108	Liver, non-regional lymph nodes	3-Endo, 2-Chemo
14*	46	T1N2M0	99% 3+	43% 2+	60% 3+	5% 1+	51	Bone, chest wall	2-Endo, 2-Chemo
15*	64	TXN1M1	95% 3+	50% 2+	99% 3+	99% 3+	Less than 1	Bone, liver	3-Endo, 1-Chemo
16*	63	T3N2M0	99%	90%	85% 3+	40% 1+	72	Peritoneum, pleura	2-Endo, 3-Chemo
17*	49	T4N3M0	60%	40%	80% 2+	Negative	37	Bone, liver, non-regional lymph nodes, ovary, pleura	2-Endo, 2-Chemo
21	49	T1N0M0	Negative	Negative	Negative	Negative	29	Chest wall, lung	0-Endo, 0-Chemo
22*	48	T3N1M0	95% 3+	95% 3+	100%	< 1%	47	Chest wall, Lung	1-Endo, 3-Chemo

If the pathology report stated “Negative” or “Positive” to describe the immunohistochemical expression of ER and PR, this is noted instead of quantified expression
Chemo chemotherapy, DX diagnosis, Endo endocrine therapy, Enroll enrollment, ER estrogen receptor, Mets metastases, PR progesterone receptor
*Indicates prior CDK4/6 inhibitor therapy

ISSN: 1465-542X