Table 4 Univariate and multivariate analysis of factors associated with pCR according to different molecular subtypes in the primary analysis cohort

HR⁺/HER2⁻

Tumor size (mm)

 D_pre^a

1.00

0.97–1.03

0.786

-

-

-

 D_early^a

0.98

0.94–1.02

0.259

-

-

-

 ∆D_early%^b

1.59

1.16–2.19

0.004

1.37

0.94–2.01

0.106

Shrinkage pattern

 CS

Ref

Ref

Ref

Ref

Ref

Ref

 DD

11.31

3.22–39.66

 < 0.001

12.08

3.34–43.75

 < 0.001

 DIO

NA

NA

NA

NA

NA

NA

 SD

NA

NA

NA

NA

NA

NA

HER2⁺

Tumor size (mm)

 D_pre^a

0.98

0.97–1.00

0.115

–

–

–

 D_early^a

0.96

0.93–0.98

0.001

–

–

–

 ∆D_early%^b

1.66

1.31–2.11

 < 0.001

1.61

1.22–2.13

0.001

Shrinkage pattern

 CS

Ref

Ref

Ref

Ref

Ref

Ref

 DD

1.06

0.48–2.34

0.896

1.04

0.45–2.44

0.921

 DIO

1.35

0.12–15.64

0.810

6.14

0.42–83.23

0.173

 SD

0.06

0.01–0.50

0.009

0.25

0.03–2.35

0.224

TNBC

Tumor size (mm)

 D_pre^a

0.99

0.97–1.01

0.258

–

–

–

 D_early^a

0.96

0.93–1.00

0.024

–

–

–

 ∆D_early%^b

1.61

1.22–2.11

0.001

–

–

–

Shrinkage pattern

 CS

Ref

Ref

Ref

–

–

–

 DD

0.50

0.14–1.77

0.282

–

–

–

 DIO

NA

NA

NA

–

–

–

 SD

NA

NA

NA

–

–

–