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Table 1 Results of the MR-measurements

From: Low-dose acetylsalicylic acid reduces local inflammation and tissue perfusion in dense breast tissue in postmenopausal women

Magnetic resonance parameter

Baseline No treatment

6 Months No treatment

Baseline -ASA

6 Months + ASA

Structural features

PDFF (%) mean ± SD

37 ± 22

40 ± 23

47 ± 23

43 ± 20

ADC (10–3 mm2 / s) mean ± SD

1.39 ± 0.41

1.28 ± 0.43

1.40 ± 0.37

1.38 ± 0.39

ADC Kurtosis (-) mean ± SD

3.38 ± 1.54

3.03 ± 0.99

3.01 ± 0.99

3.00 ± 0.61

Dynamic characteristics

Perfusion, AUC (a.u.) mean ± SD

29 ± 20

26 ± 23

30 ± 21

25 ± 17

Perfusion, tau (s)

68 ± 23

70 ± 33

69 ± 30

73 ± 25

R1 (s−1; fibroglandular, whole breast)

2.0 ± 0.2

2.0 ± 0.2

2.0 ± 0.2

2.0 ± 0.3

R2 (s−1; fibroglandular, whole breast)

13.6 ± 0.5

13.5 ± 0.5

13.7 ± 0.5

13.4 ± 0.4*

PD (%; fibroglandular, whole breast)

84 ± 4

84 ± 3.9

85 ± 3.4

85 ± 3.5

  1. The MR-protocol was divided into (i) measurements of structural features (ADC and PDFF), and (ii) dynamic characteristics on the tissue microstructure scale. Measurements were obtained in MRS voxel in upper left quadrant, left breast, alternatively in entire breast (for qMRI-measurements)
  2. PDFF Proton Density Fat Fraction, AUC Area Under (perfusion curve), tau, perfusion time constant, R1, longitudinal relaxation rate, R2, transverse relaxation rate, PD Proton Density
  3. *p < 0.05
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Breast Cancer Research

ISSN: 1465-542X

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