Fig. 2

Low-dose ASA decreased levels of proinflammatory proteins in breast tissue. Postmenopausal healthy women categorized as having BI-RADS D breast tissue were recruited from a regular mammography screening program and randomized to receive ASA 160 mg/day or no treatment for 6 months. Microdialysis was performed directly after multimodal MRI measurements to sample inflammatory proteins locally in the left breast and abdominal s.c. fat as a measure of systemic effects before and after treatment. A panel of 92 inflammatory proteins were quantified in microdialysis samples using proximity extension assay. Proteomic data were analyzed using the two-stage set-up method of Benjamini, Krieger, and Yekutieli with a FDR of 5%. Dotted horizontal line represents p < 0.05. Bold line represents FDR-corrected p < 0.013. A Volcano plot for women randomized to receive ASA 160 mg/day for 6 months. B Volcano plot for women randomized to receive no treatment for 6 months