Fig. 2

Characterization of pSTAT3 levels in patient samples. A pSTAT3 immunohistochemical analyses. Total scores of biopsy patient samples at pre-run-in (n = 20), post-run-in (n = 19) and surgery (n = 8). Comparison of pre- to post-run-in scores used Wilcoxon signed rank test. B Representative images of pSTAT3 immunohistochemical staining of patient samples at pre-run-in and post-run-in with the indicated total scores. C, pSTAT3 immunohistochemistry Total scores shown in A split into treatment groups of either monotherapy (RUX) or combination therapy (RUX + PAC) at run-in. D pSTAT3 immunohistochemistry Total scores as shown in A grouped by pCR status. E–F, IL-6 E or CRP F serum levels of blood collected at pre-run-in, post-run-in, post-neoadjuvant treatment (C5D1) and at the time of surgery in indicated treatment groups