A risk analysis of alpelisib-induced hyperglycemia in patients with advanced solid tumors and breast cancer

Breast Cancer Research

Table 1 Variables and corresponding β coefficients of the univariate, elastic net, and stepwise regression models in the training set

Variable	β univariate model^a	P	Adjusted P^b	β elastic net model (model 1)	β linear model with stepwise variable selection (model 2)
Age	0.182	< 0.001	0.003	0.024	NA
bid dosing	0.394	0.132	0.132	0.041	0.084
BMI	0.307	< 0.001	< 0.001	0.164	0.198
C-peptide	0.116	0.036	0.047	0.000	NA
Diastolic blood pressure	0.162	0.003	0.007	0.078	0.125
Dose	0.088	0.110	0.119	0.037	0.082
HbA_1c	0.202	< 0.001	0.001	0.066	0.104
HDL cholesterol	− 0.099	0.073	0.086	0.000	NA
Monocytes	0.125	0.024	0.035	0.047	0.073
Fasting plasma glucose	0.440	< 0.001	< 0.001	0.321	0.357
Red blood cells	0.128	0.021	0.034	0.012	NA
Systolic blood pressure	0.174	0.002	0.004	0.000	NA
Triglycerides	0.142	0.010	0.019	0.000	NA

^aPositive coefficients are associated with higher risk; negative coefficients are associated with lower risk. All variables were standardized to have a mean of 0 and an SD of 1 using training set data. ^bAdjusted P values for simple multiple testing procedures using Benjamini and Hochberg step-up false discovery rate-controlling procedure
bid, twice daily; BMI, body mass index; HbA_1c, glycated hemoglobin; HDL, high-density lipoprotein; NA, not applicable

ISSN: 1465-542X