Fig. 5
Enhanced ERK1/2 activity in mammary epithelium of 30-month-old Her2t/w/Adamts18−/− mice. (A, C, E) Representative immunochemistry staining of total ERK (A), Thr202/Tyr204-phosphorylated ERK (C), and fibronectin (FN) (E) in mammary epithelium. Scale bar, 100 μm. (B, D, F) Quantification of ERK (B), pERK (D), and FN-positive areas (F) was performed with Image Pro Plus. Each dot or square represents an individual. Data are expressed as mean ± SD (n = 4). **p < 0.01; ***p < 0.001; ns, not significant; Student’s t-test, two tailed