Fig. 6

USP5 is positively correlated with PFKP expression in TNBC and is associated with poor prognosis of TNBC patients. a Representative images of IHC staining of USP5 and PFKP in serial sections of the same TNBC tumor. Scale bars, 100 μm. b A positive correlation between the expression of USP5 and PFKP in the 172 human TNBC carcinoma samples. r = 0.223, P = 0.003. c Concomitantly high expression of USP5 and PFKP correlates positively with the TNM stage in human TNBC carcinoma samples. r = 0.369, P < 0.001. d Kaplan–Meier curves showed that the overall survival of patients with concomitantly high USP5 and PFKP expression in TNBC tumors was shorter than that of those with concomitantly low USP5 and PFKP expression. Log-rank P = 0.0004. e A schematic diagram of USP5 promotes TNBC progression and aerobic glycolysis through deubiquitinating and stabilizing PFKP