Fig. 1

PFKP protein expression is frequently upregulated in TNBC and is associated with poor prognosis in TNBC patients. a The protein expression of PFKP is higher in TNBC than in normal breast tissues in CPTAC data. ***P < 0.001. b The survival curves of TNBC patients with high or low expression of PFKP protein based on the Kaplan–Meier plotter platform. c Representative images of IHC staining of PFKP in TNBC carcinoma and para-carcinoma tissues. Scale bars, 100 μm. d PFKP protein expression in TNBC carcinoma tissues (n = 172) was significantly higher than that in para-carcinoma tissues (n = 130). r = 0.268, P < 0.001. e Representative images of IHC staining of PFKP in TNBC carcinoma tissues. Scale bars, 100 μm. f The expression of PFKP correlates positively with the TNM stage in human TNBC carcinoma samples. r = 0.206, P = 0.026. g High expression of PFKP is correlated with poor overall survival of TNBC patients. Log-rank P = 0.0037. h The protein expression of PFKP in TNBC cell lines (MDA-MB-231 and SUM-159) and normal breast cell line (MCF-10A)