A genome-wide association study of contralateral breast cancer in the Women’s Environmental Cancer and Radiation Epidemiology Study

Table 2 Areas under the receiver operating characteristic curve for contralateral breast cancer risk models

Model	AUC (95% CI)	AUC improvement (95% CI)	P
WECARE I + II
Risk factors^a	60.7 (58.5–63.0)	Ref	Ref
PRS + Risk factors	62.4 (60.2–64.7)	1.7 (0.4–3.0)	0.01
WECARE I^b
Risk factors	63.0 (60.0–66.1)	Ref	Ref
Risk factors + BRCA1/2 mutations	65.5 (62.5–68.6)	2.5 (0.1–4.2)	0.003
PRS + Risk factors	65.1 (62.0–68.1)	2.0 (0.3–3.8)	0.03
PRS + Risk factors + BRCA1/2 mutations^c	67.7 (64.7–70.7)	4.7 (2.4–7.0)	< 0.0001

AUC, area under the curve; CI, confidence interval; PRS, polygenic risk score
^aRisk factors included age at first breast cancer diagnosis, age at menarche, age at menopause, number of full-term pregnancies, stage of first breast cancer, histology of first breast cancer, family history of breast cancer, chemotherapy, and hormone therapy
^bInformation about BRCA1/2 deleterious mutations was only available in the WECARE I Study
^cWhen comparing PRS + Risk factors + BRCA1/2 mutations to PRS + Risk factors model, the AUC improvement and P are: 2.2 (95% CI 0.5–3.8); 0.01

ISSN: 1465-542X