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Fig. 7 | Breast Cancer Research

Fig. 7

From: Protein disulfide isomerase family member 4 promotes triple-negative breast cancer tumorigenesis and radiotherapy resistance through JNK pathway

Fig. 7

PDAI4 via JNK/c‐Jun signaling to enhance tumorigenesis and RT resistance. A Western blot analysis of JNK/c‐Jun signaling pathway‐related proteins, the results revealed that JNK, c‐Jun, p‐JNK, p‐c‐Jun expression levels in TNBC cells with PDIA4 knockdown or overexpression with/without IR. B, C and D The target cells were transfected with shRNA3 or shNC with/without IR, then cultured with SP600125, cell proliferation was tested using the CCK‐8 assay, apoptosis was detected by FACS assay, and the protein was analyzed by western blot. E Western blot analysis of TAX1BP1 expression after transfection. F, G and H The target cells with or without TAX1BP1 overexpression following treatment with IR, cell proliferation was tested using the CCK‐8 assay, apoptosis was detected by FACS assay, and the protein was analyzed by western blot

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Breast Cancer Research

ISSN: 1465-542X

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