Effect of histological breast cancer subtypes invasive lobular versus non-special type on survival in early intermediate-to-high-risk breast carcinoma: results from the SUCCESS trials

Table 2 Effects of histological tumor type (ILC vs. NST) on DFS, OS, BCSS, and DDFS

Survival endpoint		Univariable Cox regression model			Adjusted multivariable Cox regression model			p value for 2-way interaction (histological tumor type × nodal status)
Survival endpoint		Hazard ratio	95% CI	p value	Hazard ratio	95% CI	p value
DFS	pN0/pN1							< 0.001
	ILC vs. NST	0.55	0.39–0.77	< 0.001	0.60	0.42–0.86	0.005
	pN2/pN3
	ILC vs. NST	1.38	1.05–1.82	0.023	1.40	1.03–1.91	0.033
OS	pN0/pN1							0.005
	ILC vs. NST	0.60	0.39– 0.94	0.025	0.66	0.41–1.07	0.091
	pN2/pN3
	ILC vs. NST	1.54	1.10–2.15	0.011	1.60	1.09–2.34	0.015
BCSS	pN0/pN1							0.008
	ILC vs. NST	0.56	0.34–0.93	0.024	0.70	0.41–1.20	0.190
	pN2/pN3
	ILC vs. NST	1.56	1.09–2.24	0.016	1.71	1.12–2.59	0.012
DDFS	pN0/pN1							0.007
	ILC vs. NST	0.55	0.37–0.82	0.003	0.63	0.41–0.95	0.029
	pN2/pN3
	ILC vs. NST	1.21	0.87–1.67	0.254	1.35	0.94–1.94	0.108

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