| AUC (95% CI) | Increase in AUC from combined versus BWHS model (95% CI) | p-value |
---|---|---|---|
All invasive breast cancers (N = 922) | |||
 BWHS model only | 0.577 (0.556–0.598) |  |  |
 PRS only | 0.584 (0.563–0.605) |  |  |
 BWHS model + PRS | 0.623 (0.603–0.644) | 0.046 (0.023–0.069) | < 0.0001 |
ER-positive breast cancer (N = 555) | |||
 BWHS model only | 0.594 (0.572–0.617) |  |  |
 PRS only | 0.595 (0.571–0.620) |  |  |
 BHS model + PRS | 0.627 (0.603–0.651) | 0.033 (0.008–0.057) | 0.0099 |
ER-negative breast cancer (N = 296) | |||
 BWHS model only | 0.536 (0.509–0.563) |  |  |
 PRS only | 0.576 (0.549–0.603) |  |  |
 BWHS model + PRS | 0.597 (0.568–0.627) | 0.061 (0.031–0.093) | 0.0001 |
Age < 45 years at breast cancer diagnosis or control selection (N  = 208) | |||
 BWHS model only | 0.546 (0.507–0.586) |  |  |
 PRS only | 0.587 (0.551–0.623) |  |  |
 BWHS model + PRS | 0.608 (0.569–0.647) | 0.062 (0.022–0.101) | 0.0025 |
Age ≥ 45 years at breast cancer diagnosis or control selection (N = 714) | |||
 BWHS model only | 0.586 (0.563–0.609) |  |  |
 PRS only | 0.583 (0.559–0.608) |  |  |
 BWHS model + PRS | 0.630 (0.606–0.653) | 0.044 (0.020–0.068) | 0.0003 |