Table 3 Uni- and multivariable Cox regression analysis for DFS and OS for patients with HR + , HER2-, pT1-3 IDC or ILC
Variable | Univariable analysis | Multivariable analysis | ||||
|---|---|---|---|---|---|---|
Hazard ratio (95% CI) | p-value | Hazard ratio (95% CI) | p-value | |||
Model for disease-free survival (120 months) | ||||||
Age (years) | 0.99 | (0.99–1.00) | 0.20 | |||
pT | < 0.001 | |||||
1 (reference) | 1.00 | |||||
2 | 1.59 | (1.28–1.97) | < 0.001 | |||
3 | 1.66 | (1.01–2.72) | 0.04 | |||
pN | < 0.001 | 0.20 | ||||
0 (reference) | 1.00 | 1.00 | ||||
1 | 1.30 | (1.02_1.65) | 0.03 | 1.20 | (0.73–1.97) | 0.46 |
2 | 2.25 | (1.60–3.18) | < 0.001 | 1.50 | (0.74–3.02) | 0.26 |
3 | 4.61 | (2.96–7.18) | < 0.001 | 2.29 | (1.03–5.09) | 0.04 |
Histologic tumor type | ||||||
Ductal (reference) | 1.00 | 1.00 | ||||
Lobular | 1.19 | (0.90–1.59) | 0.20 | 1.77 | (1.08–2.90) | 0.02 |
Grading | 0.004 | |||||
1 (reference) | 1.00 | |||||
2 | 1.29 | (0.88–1.89) | 0.19 | |||
3 | 1.76 | (1.19–2.60) | 0.005 | |||
LVSI | ||||||
No (reference) | 1.00 | 1.00 | ||||
Yes | 1.78 | (1.39–2.28) | < 0.001 | 1.75 | (1.12–2.74) | 0.01 |
Ki-67 | 1.01 | (1.00–1.02) | 0.02 | |||
ER Allred score | 0.83 | (0.78–0.89) | < 0.001 | 0.84 | (0.78–0.91) | < 0.001 |
PR Allred score | 0.94 | (0.89–1.00) | 0.07 | |||
Model for overall survival (120 months) | ||||||
Age (years) | 1.03 | (1.01–1.04) | < 0.001 | 1.05 | (1.02–1.07) | < 0.001 |
pT | < 0.001 | |||||
1 (reference) | 1.00 | |||||
2 | 2.16 | (1.58–2.95) | < 0.001 | |||
3 | 1.41 | (0.62–3.25) | 0.49 | |||
pN | < 0.001 | |||||
0 (reference) | 1.00 | |||||
1 | 1.96 | (1.36–2.82) | < 0.001 | |||
2 | 4.35 | (2.77–6.83) | < 0.001 | |||
3 | 7.42 | (4.16–13.25) | < 0.001 | |||
Histologic tumor type | ||||||
Ductal (reference) | 1.00 | |||||
Lobular | 1.24 | (0.81–1.88) | 0.32 | |||
Grading | 0.014 | |||||
1 (reference) | 1.00 | |||||
2 | 1.68 | (0.90–3.16) | 0.11 | |||
3 | 2.36 | (1.24–4.49) | 0.009 | |||
LVSI | ||||||
No (reference) | 1.00 | 1.00 | ||||
Yes | 2.34 | (1.64–3.34) | < 0.001 | 3.62 | (1.92–6.82) | < 0.001 |
Ki-67 | 1.02 | (1.00–1.04) | 0.01 | |||
ER Allred score | 0.81 | (0.74–0.88) | < 0.001 | 0.80 | (0.73–0.89) | < 0.001 |
PR Allred score | 0.94 | (0.85–1.03) | 0.19 | |||