Fig. 3

Integrative analysis of hierarchical clustering using HER2-associated genes. A gene expression-based correlation matrix was used to cluster 366 MBC cases (see Additional file 1: Figure S3 for the accompanying heatmap). Relationships with ERBB2 log2-CN (dashed line indicates CN of 2, red indicate samples labeled as HER2+ in our analysis), ERBB2 mutation (amino acid changing events in: Ex, Extracellular domain, Tk, Tyrosine Kinase domain), PAM50 molecular subtype estimation, anti-HER2 therapy (AHT) given prior to biopsy and the ER status are shown