Fig. 2

Multivariable model prediction of PFS. Kaplan–Meier progression-free survival curves of patients grouped by risk score. a Patients from our own cohort, labeling samples with a risk score ≥ 2.25 as high risk (see “Methods”) using five features: the number of lines of prior treatment, mutations of PIK3CA or CDK12, gain of chromosome 8p11.23 and a high contribution of gene signature DBS3. b Validation cohort, using PIK3CA, CDK12 mutation and Amp-peak 6 gain in the model as the only available features for the validation samples. Since these 3 features were mutually exclusive in this cohort, if any events of these 3 features were present the sample was assigned as high risk, the sample was assigned as high risk. p values derived from log-rank test