Fig. 1

Differences between MBC and PBC. Levels and frequencies in unpaired PBC (green) and MBC (orange) for a total number of variants, being single-nucleotide variants and indels, and number of SVs, b % of relative contribution of the DBS2 mutational signature in HER2+ (left) and HER2− (right), showing that enrichment of the DBS2 signature in metastatic tumors is subtype-specific. p values derived from FDR-corrected MWU tests