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Fig. 8 | Breast Cancer Research

Fig. 8

From: Key regulator PNPLA8 drives phospholipid reprogramming induced proliferation and migration in triple-negative breast cancer

Fig. 8

Silencing of PNPLA8 suppresses the PI3K/Akt/GSK3β and MAPK pathways. A GSEA results showed that MAP4K4 and MAPK10 pathways were enriched in the PNPLA8-positive cluster within the TCGA breast cancer data sets. NES, normalized enrichment score; NOM, normalized; FDR, false discovery rate. B Correlation analysis of MAP3K2, MAP4K3 and PIK3C2A with PNPLA8 mRNA levels in TCGA breast cancer tissues. C Protein expression levels of PNPLA8, phospho-Akt (ser473), Akt, phospho-Gsk3β (ser9), phospho-Erk1/2 (Thr202/Tyr204), Erk1/2 in SUM159PT and Hs578T cell lines treated with PNPLA8 siRNA or scrambled siRNA combined with the treatment of PGE2 (1 μM) or 20-HETE (10 nM) for 48 h. GAPDH was used as loading control

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Breast Cancer Research

ISSN: 1465-542X

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