Fig. 4

PNPLA8 expression levels in breast cancer tissues and its correlation with disease development. A Representative IHC staining of PNPLA8 expression from breast cancer TMAs. Scale bar = 200 μm. B PNPLA8 expression levels in normal breast tissues (n = 7), adjacent normal breast tissues (n = 31), cancer adjacent breast tissues (n = 4) and invasive breast cancer tissues (n = 280). C PNPLA8 expression levels in invasive lobular and invasive ductal breast cancer tissues. D PNPLA8 expression levels in tumor tissues of Luminal, HER2+ and TNBC subtypes. E PNPLA8 expression levels in histological grade 1 (G1), 2 (G2) and 3 (G3) breast cancer patients. F PNPLA8 expression levels in different TNM stages of breast cancer patients. G PNPLA8 expression levels in tumor tissues with no (N0), 1 ~ 3 (N1) and 4 ~ 9 (N2) lymph node metastases. *p < 0.05, ***p < 0.0001