Fig. 1

Lipid remodeling in triple-negative breast cancer cell lines. A PCA score scatter plot of lipid features in TNBC (MDA-MB-231, SUM159PT, Hs578T, MDA-MB-468, SUM149PT) and immortal human mammary epithelial cell lines (MCF10A, MCF12A). The x-axis and y-axis indicate the first principal component and second principal component, respectively. B OPLS-DA score scatter plot of TNBC cell lines compared to immortal human mammary epithelial cell lines. C Heatmap of log normalized abundance of lipid classes in TNBC and nonmalignant human mammary epithelial cell lines. Each cell line is represented by 5 biological replicates. Red boxes outline phospholipids increased in TNBC cells, and yellow boxes outline phospholipids decreased in TNBC cells. D The percentage of significantly upregulated, downregulated, and unchanged species of each lipid classes in Claudin-low TNBC cell lines (MDA-MB-231, SUM159PT and Hs578T) compared to immortal human mammary epithelial cell lines. p values < 0.05 were considered significant