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Fig. 3 | Breast Cancer Research

Fig. 3

From: The chromatin architectural regulator SND1 mediates metastasis in triple-negative breast cancer by promoting CDH1 gene methylation

Fig. 3

SND1 knockdown regulates a group of DNA methylation and cell motility genes in TNBC. A Hierarchical clustering of scrambled shRNAs (Scramble) or SND1 shRNAs (SND1-sh1/sh2) transfection were shown. After SND1 knocking down, 17 downregulated and 22 upregulated genes were screened out and annotated (green, downregulated gene; red, upregulated gene). B The KEGG enriched pathways among the SND1 potential regulatory targets were listed at the red box. C Venn plot showed SND1 downstream target genes. D Network plot descripting relationships among SND1, DNMT3A and CDH1 (bold red circle) and other related pathway members (bold black circle)

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Breast Cancer Research

ISSN: 1465-542X

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