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Fig. 2 | Breast Cancer Research

Fig. 2

From: The chromatin architectural regulator SND1 mediates metastasis in triple-negative breast cancer by promoting CDH1 gene methylation

Fig. 2

SND1 promotes TNBC cell migration and invasion. A, B qRT-PCR and Western blotting results of SND1 levels in MDA-MB-231 and BT549 cells of wild type control (wild type), scramble control (scramble), SND1 knocking down (SND1-sh1; SND1-sh2; n = 3; **, P < 0.01). C The wound healing assay results of aforementioned breast cancer cells (n = 3; **, P < 0.01). D The transwell assay results of above-mentioned cells (n = 3; **, P < 0.01). E MDA-MB-231 cells stably expressing scramble shRNA (scramble) or SND1 shRNAs (SND1-sh1, sh2) were injected into caudal vein of SCID mice. The pulmonary metastasis luminous signals were measured by luminous CCD system (n = 8; ***, P < 0.001). F K-M survival analysis showed that mice inoculated with SND1knocking down cells (sh1/sh2) had longer survival time than the control mice (scramble, ***, P < 0.001)

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Breast Cancer Research

ISSN: 1465-542X

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