Table 3 Age-adjusted and multivariable-adjusted hazard ratios for the association between body fatness and postmenopausal breast cancer overall
From: Trajectories of body mass index in adulthood and risk of subtypes of postmenopausal breast cancer
Study sample (n = 148,866) | Cases | Age-adjusted HR (95% CI) | Complete-case study sample (n = 142,771) | Cases | MV-adjusted HR (95% CI)a | |
|---|---|---|---|---|---|---|
(n = 7223) | (n = 6933) | |||||
Age at onset (yrs)b | ||||||
BMI ≥ 25 | ||||||
Never OW | 83,606 | 3939 | Ref | 79,966 | 3766 | Ref |
< 40 | 26,375 | 1220 | 1.01 (0.95–1.08) | 25,112 | 1173 | 1.00 (0.93–1.07) |
40–49 | 25,208 | 1356 | 1.16 (1.09–1.23) | 24,422 | 1311 | 1.14 (1.07–1.21) |
≥ 50 | 13,677 | 708 | 1.18 (1.09–1.28) | 13,271 | 683 | 1.16 (1.07–1.26) |
ptrendc | < 0.01 | < 0.01 | ||||
BMI ≥ 30 | ||||||
Never OB | 133,840 | 6504 | Ref | 128,327 | 6232 | Ref |
< 40 | 3242 | 120 | 0.80 (0.66–0.95) | 3082 | 119 | 0.81 (0.68–0.97) |
40–49 | 5858 | 286 | 1.02 (0.91–1.15) | 5640 | 282 | 1.02 (0.91–1.15) |
≥ 50 | 5926 | 313 | 1.17 (1.05–1.32) | 5722 | 300 | 1.14 (1.02–1.29) |
ptrendc | 0.03 | 0.06 | ||||
Duration (per 10 yrs)b | ||||||
BMI ≥ 25 | 65,260 | 3284 | 1.02 (1.00–1.04) | 62,805 | 3167 | 1.02 (0.99–1.04) |
BMI ≥ 30 | 15,026 | 719 | 0.99 (0.94–1.05) | 14,444 | 701 | 0.99 (0.93–1.05) |
Intensity (per 100 units)b | ||||||
OWY | 65,260 | 3284 | 1.00 (0.95–1.06) | 62,805 | 3167 | 1.00 (0.94–1.05) |
OBY | 15,026 | 719 | 0.92 (0.78–1.08) | 14,444 | 701 | 0.92 (0.78–1.08) |
Trajectoriesd, e | ||||||
Normal-stable | 62,729 | 3031 | Ref | 65,507 | 3166 | Ref |
Normal-overweight | 58,079 | 2864 | 1.03 (0.98–1.08) | 60,440 | 2987 | 1.02 (0.96–1.07) |
Normal-obesity | 17,374 | 854 | 1.03 (0.95–1.11) | 18,117 | 885 | 1.01 (0.94–1.09) |
Overweight-obesity | 3454 | 144 | 0.88 (0.74–1.04) | 3609 | 145 | 0.88 (0.75–1.05) |
Obesity-decrease | 1135 | 40 | 0.70 (0.51–0.96) | 1193 | 40 | 0.71 (0.52–0.96) |
ptrendc | 0.45 | 0.28 | ||||