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Table 3 Covariate-adjusted Least Square Means of Volumetric Percent Density (VPD) by Quartiles of Lipid Species that were Significantly Associated with VPD at a Bonferroni P-value < 0.05 a,b,c

From: Lipidome of mammographic breast density in premenopausal women

 

Q1 LSM (95% CI)

Q2 LSM (95% CI)

Q3 LSM (95% CI)

Q4 LSM (95% CI)

p-trend

FDR p-trend

Bonferroni p-trend

Phospholipids

       

PC(18:0/20:3)

9.0 (8.2–10.0)

8.4 (7.6–9.3)

8.1 (7.3–9.0)

7.1 (6.4–7.9)

1.2E-05

0.0001

0.03

PC(18:1/18:1)

7.4 (6.7–8.2)

8.2 (7.4–9.0)

8.3 (7.4–9.2)

9.5 (8.6–10.6)

1.1E-05

0.0001

0.03

LPC(18:1)

7.4 (6.6–8.2)

7.7 (7.0–8.5)

9.1 (8.2–10.1)

8.8 (7.9–9.8)

0.0006

0.002

1

PI(18:1/18:1)

7.5 (6.7–8.3)

7.7 (7.0–8.6)

8.4 (7.6–9.3)

9.4 (8.5–10.5)

6.3E-06

8.8E-05

0.02

Sphingolipids

       

LCER(14:0)

7.4 (6.7–8.2)

8.2 (7.4–9.0)

8.6 (7.8–9.6)

9.6 (8.6–10.7)

1.2E-05

0.0001

0.03

Neutral complex lipids

       

CE(20:3)

9.3 (8.4–10.3)

8.2 (7.4–9.0)

7.7 (6.9–8.5)

7.1 (6.4–8.0)

2.4E-06

5.0E-05

0.006

DAG(14:0/18:2)

8.8 (8.0–9.8)

8.7 (7.8–9.6)

8.2 (7.4–9.1)

7.1 (6.4–7.9)

7.9E-06

0.0001

0.02

DAG(16:0/18:2)

9.4 (8.5–10.5)

9.1 (8.2–10.1)

7.4 (6.7–8.2)

7.2 (6.5–8.0)

6.5E-07

2.7E-05

0.002

DAG(16:0/18:3)

9.2 (8.3–10.2)

9.1 (8.2–10.1)

7.6 (6.8–8.4)

7.2 (6.5–8.0)

2.7E-06

5.2E-05

0.007

DAG(16:1/18:2)

9.3 (8.3–10.3)

8.7 (7.8–9.6)

7.7 (6.9–8.5)

7.0 (6.3–7.9)

2.6E-06

5.2E-05

0.007

DAG(18:0/18:2)

9.1 (8.2–10.2)

8.9 (8.1–9.9)

7.6 (6.8–8.4)

7.3 (6.6–8.1)

2.6E-05

0.0002

0.07

DAG(18:2/20:4)

9.4 (8.5–10.4)

8.3 (7.5–9.2)

8.0 (7.2–8.9)

7.3 (6.5–8.1)

2.3E-05

0.0002

0.06

DAG(18:2/22:4)

9.0 (8.1–10.0)

8.4 (7.6–9.3)

7.8 (7.0–8.7)

7.2 (6.4–8.0)

3.0E-05

0.0002

0.08

TAG50:2-FA16:0

9.2 (8.3–10.2)

9.1 (8.2–10.0)

7.7 (7.0–8.6)

7.0 (6.3–7.8)

1.5E-07

1.2E-05

0.004

TAG50:2-FA18:2

9.3 (8.4–10.3)

8.9 (8.0–9.9)

7.9 (7.1–8.7)

7.1 (6.4–7.9)

3.2E-07

1.8E-05

0.0008

TAG50:3-FA16:0

9.4 (8.5–10.4)

9.2 (8.3–10.1)

7.5 (6.8–8.3)

6.9 (6.2–7.7)

1.2E-08

3.4E-06

3.1E-05

TAG50:3-FA18:2

9.1 (8.2–10.1)

9.0 (8.2–10.0)

7.6 (6.8–8.4)

7.1 (6.3–7.9)

1.3E-06

3.7E-05

0.003

TAG50:3-FA18:3

8.8 (8.0–9.8)

9.3 (8.4–10.3)

8.0 (7.2–8.8)

7.2 (6.5–7.9)

3.6E-06

6.1E-05

0.009

TAG50:4-FA14:0

9.0 (8.1–10.0)

8.2 (7.4–9.1)

8.2 (7.4–9.1)

7.1 (6.4–7.9)

1.6E-05

0.0002

0.04

TAG50:4-FA18:2

9.0 (8.1–9.9)

8.4 (7.6–9.3)

8.1 (7.3–9.0)

7.1 (6.3–7.9)

1.1E-05

0.0001

0.03

TAG51:3-FA16:0

9.4 (8.4–10.4)

8.6 (7.7–9.5)

7.8 (7.1–8.7)

7.1 (6.4–7.9)

1.9E-06

4.6E-05

0.005

TAG52:2-FA18:2

9.3 (8.4–10.4)

8.8 (7.9–9.7)

7.6 (6.8–8.4)

7.3 (6.6–8.1)

1.4E-05

0.0001

0.04

TAG52:2-FA20:2

9.0 (8.1–10.0)

8.7 (7.9–9.6)

8.5 (7.6–9.4)

6.9 (6.3–7.7)

5.3E-07

2.4E-05

0.001

TAG52:3-FA16:0

9.4 (8.5–10.5)

8.5 (7.7–9.4)

7.8 (7.0–8.7)

7.3 (6.5–8.1)

7.6E-06

9.9E-05

0.02

TAG52:3-FA18:1

9.4 (8.4–10.4)

8.5 (7.7–9.4)

7.9 (7.1–8.7)

7.2 (6.5–8.0)

3.7E-06

6.2E-05

0.009

TAG52:3-FA18:2

9.4 (8.5–10.4)

8.5 (7.7–9.4)

7.8 (7.1–8.7)

7.2 (6.5–8.0)

4.0E-06

6.5E-05

0.01

TAG52:3-FA20:0

9.5 (8.5–10.5)

8.6 (7.8–9.5)

7.8 (7.0–8.6)

7.1 (6.4–7.9)

5.4E-07

2.4E-05

0.001

TAG52:3-FA20:3

8.9 (8.0–9.8)

9.1 (8.2–10.0)

8.1 (7.3–9.0)

7.0 (6.3–7.8)

7.0E-07

2.7E-05

0.002

TAG52:3-FA22:1

9.2 (8.3–10.2)

8.8 (7.9–9.7)

7.9 (7.1–8.8)

7.1 (6.4–7.9)

1.9E-06

4.5E-05

0.005

TAG52:4-FA14:0

9.0 (8.1–9.9)

8.4 (7.6–9.3)

8.3 (7.5–9.2)

6.9 (6.2–7.7)

1.3E-06

3.6E-05

0.003

TAG52:4-FA16:0

9.6 (8.7–10.6)

8.8 (8.0–9.8)

7.4 (6.7–8.2)

7.3 (6.6–8.1)

4.7E-07

2.3E-05

0.001

TAG52:4-FA18:2

9.5 (8.6–10.5)

8.7 (7.8–9.6)

7.6 (6.9–8.4)

7.2 (6.5–8.0)

3.8E-07

2.0E-05

0.001

TAG52:4-FA20:0

9.6 (8.6–10.6)

8.8 (8.0–9.8)

7.4 (6.7–8.2)

7.3 (6.6–8.1)

5.3E-07

2.4E-05

0.001

TAG52:4-FA20:2

9.2 (8.3–10.2)

8.4 (7.5–9.3)

7.8 (7.0–8.6)

7.3 (6.5–8.1)

5.2E-05

0.0004

0.13

TAG52:4-FA22:1

9.4 (8.5–10.5)

8.6 (7.8–9.6)

7.6 (6.8–8.4)

7.3 (6.6–8.1)

4.1E-06

6.6E-05

0.01

TAG52:5-FA16:0

9.4 (8.5–10.4)

8.9 (8.0–9.9)

7.6 (6.9–8.5)

7.2 (6.5–8.0)

1.1E-06

3.3E-05

0.003

TAG52:5-FA20:3

9.2 (8.4–10.2)

8.1 (7.3–9.0)

8.1 (7.3–9.1)

7.0 (6.3–7.8)

2.4E-06

5.0E-05

0.006

TAG52:6-FA20:4

9.0 (8.1–9.9)

8.9 (8.1–9.9)

7.8 (7.0–8.6)

7.2 (6.5–8.0)

1.5E-05

0.0002

0.04

TAG53:4-FA16:0

9.5 (8.5–10.5)

8.4 (7.6–9.3)

7.9 (7.2–8.8)

7.2 (6.5–8.0)

4.5E-06

7.0E-05

0.01

TAG54:3-FA16:0

8.9 (8.0–9.9)

8.7 (7.8–9.6)

7.9 (7.1–8.8)

7.1 (6.4–7.9)

2.1E-05

0.0002

0.05

TAG54:4-FA16:0

9.1 (8.2–10.1)

8.8 (8.0–9.8)

7.6 (6.9–8.5)

7.1 (6.4–7.9)

2.8E-06

5.3E-05

0.007

TAG54:4-FA20:2

9.2 (8.3–10.2)

8.2 (7.4–9.1)

8.1 (7.3–8.9)

7.3 (6.5–8.1)

6.3E-05

0.0004

0.16

TAG54:4-FA20:3

9.0 (8.1–10.0)

8.8 (8.0–9.7)

7.9 (7.1–8.8)

7.1 (6.4–7.9)

5.5E-06

8.1E-05

0.01

TAG54:5-FA16:0

9.4 (8.4–10.4)

8.9 (8.1–9.9)

7.7 (6.9–8.6)

6.9 (6.2–7.7)

6.4E-08

7.5E-06

0.0002

TAG54:5-FA20:2

9.1 (8.2–10.1)

8.4 (7.6–9.3)

7.8 (7.0–8.7)

7.4 (6.6–8.2)

0.0003

0.001

0.71

TAG54:5-FA20:3

9.5 (8.6–10.5)

8.4 (7.6–9.3)

7.8 (7.0–8.6)

7.0 (6.3–7.8)

2.9E-07

1.7E-05

0.0007

TAG54:5-FA20:4

9.5 (8.5–10.5)

8.8 (7.9–9.7)

7.6 (6.9–8.5)

7.2 (6.5–8.0)

6.6E-06

9.0E-05

0.02

TAG54:6-FA16:0

9.7 (8.7–10.7)

8.7 (7.8–9.6)

7.9 (7.1–8.7)

7.0 (6.3–7.7)

2.6E-08

5.2E-06

6.8E-05

TAG54:6-FA20:3

9.4 (8.5–10.4)

8.3 (7.5–9.2)

7.7 (6.9–8.5)

7.2 (6.4–8.0)

3.7E-06

6.2E-05

0.01

TAG54:6-FA20:4

9.8 (8.8–10.9)

8.6 (7.8–9.6)

7.6 (6.8–8.4)

7.0 (6.3–7.8)

8.1E-08

8.7E-06

0.0002

TAG54:7-FA20:4

9.5 (8.6–10.5)

8.9 (8.0–9.8)

7.4 (6.7–8.3)

6.9 (6.2–7.7)

4.4E-08

6.5E-06

0.0001

TAG55:7-FA20:4

9.2 (8.2–10.2)

8.8 (8.0–9.8)

7.7 (7.0–8.6)

7.2 (6.5–8.1)

3.9E-06

6.4E-05

0.01

TAG56:4-FA22:4

9.1 (8.2–10.1)

9.0 (8.2–10.0)

7.7 (6.9–8.5)

7.1 (6.4–7.9)

2.0E-06

4.7E-05

0.005

TAG56:5-FA22:4

9.1 (8.2–10.2)

8.7 (7.8–9.6)

8.0 (7.2–8.9)

7.2 (6.5–8.0)

1.4E-05

0.0001

0.04

TAG56:6-FA22:4

9.6 (8.7–10.7)

8.6 (7.8–9.5)

7.6 (6.9–8.5)

7.1 (6.4–7.9)

1.9E-07

1.3E-05

0.0005

TAG56:7-FA22:4

9.3 (8.4–10.3)

8.9 (8.0–9.8)

7.5 (6.7–8.3)

7.3 (6.5–8.1)

7.0E-06

9.4E-05

0.02

  1. aModels were adjusted for age (continuous), age at menarche (continuous), body fat % (continuous), race (non-Hispanic white, non-Hispanic black, other), family history of breast cancer (yes, no), oral contraceptive use (never, less than 1 year, 1–4 years, 5–9 years, more than 10 years), alcohol consumption (never, less than 1 drink per week, 1–2 drinks per week, 3–5 drinks per week, and 6 + drinks per week), parity/age at first birth (nulliparous, 1–2 children & < 25 years, 1–2 children & 25–29 years, 1–2 children &, ≥ 30 years, ≥ 3 children & < 25 years, ≥ 3 children & ≥ 25 years) and body shape at age 10 (1&2, 3&4, 5, 6–9)
  2. bVolumetric percent density was log10 transformed and coefficients were back-transformed (10^β)
  3. Abbreviations: phosphatidylcholine (PC), lysophosphatidylcholine (LPC), phosphatidylinositol (PI), lactosylceramide (LCER), cholesteryl ester (CE), diacylglycerol (DAG), triacylglycerol (TAG), quartiles 1–4 (Q1-4), least square mean (LSM), confidence interval (CI), false discovery rate (FDR)
  4. cLipid species presented were associated with volumetric percent density in multivariable linear regression analyses, after Bonferroni correction and bolded if the Bonferroni p-trend is < 0.05
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Breast Cancer Research

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