Lipid pathway a,b,c | Q1LSM (95% CI) | Q2LSM (95% CI) | Q3LSM (95% CI) | Q4LSM (95% CI) | p-trend | FDR p-trend | Bonferroni p-trend |
|---|
Phospholipids | Â | Â | Â | Â | Â | Â | Â |
PC | 8.5 (7.7–9.5) | 8.4 (7.5–9.3) | 7.9 (7.1–8.8) | 8.1 (7.3–9.0) | 0.30 | 0.55 | 1 |
LPC | 7.6 (6.9–8.5) | 8.4 (7.6–9.3) | 8.4 (7.6–9.3) | 8.5 (7.7–9.5) | 0.07 | 0.18 | 1 |
PE | 8.7 (7.8–9.6) | 8.0 (7.2–8.9) | 8.3 (7.5–9.3) | 7.9 (7.1–8.8) | 0.15 | 0.35 | 1 |
LPE | 8.1 (7.3–9.0) | 8.1 (7.3–9.0) | 8.3 (7.5–9.2) | 8.4 (7.6–9.3) | 0.46 | 0.63 | 1 |
PI | 8.3 (7.5–9.2) | 8.4 (7.6–9.4) | 8.2 (7.4–9.1) | 8.0 (7.2–8.9) | 0.43 | 0.63 | 1 |
Sphingolipids | Â | Â | Â | Â | Â | Â | Â |
CER | 9.0 (8.1–9.9) | 8.4 (7.6–9.3) | 7.6 (6.9–8.5) | 7.8 (7.1–8.7) | 0.008 | 0.04 | 0.33 |
DCER | 9.2 (8.3–10.2) | 8.2 (7.4–9.1) | 7.9 (7.1–8.7) | 7.5 (6.8–8.4) | 0.0004 | 0.003 | 0.02 |
HCER | 7.7 (6.9–8.5) | 8.5 (7.6–9.4) | 8.2 (7.4–9.1) | 8.7 (7.8–9.6) | 0.05 | 0.14 | 1 |
LCER | 7.5 (6.8–8.3) | 8.3 (7.5–9.2) | 8.2 (7.4–9.1) | 9.3 (8.3–10.3) | 0.0002 | 0.002 | 0.009 |
SM | 8.3 (7.5–9.2) | 8.6 (7.8–9.6) | 8.3 (7.5–9.2) | 7.6 (6.8–8.4) | 0.05 | 0.15 | 1 |
Neutral complex lipids | Â | Â | Â | Â | Â | Â | Â |
CE | 8.4 (7.6–9.3) | 8.7 (7.8–9.6) | 8.2 (7.4–9.1) | 7.5 (6.7–8.3) | 0.01 | 0.04 | 0.42 |
DAG | 9.0 (8.1–9.9) | 8.5 (7.7–9.5) | 8.1 (7.3–9.0) | 7.3 (6.6–8.1) | 0.0002 | 0.002 | 0.008 |
TAG | 8.9 (8.0–9.9) | 9.2 (8.3–10.2) | 7.7 (7.0–8.5) | 7.2 (6.5–8.1) | 1.7E-05 | 0.0003 | 0.0007 |
MAG | 8.6 (7.7–9.5) | 8.1 (7.3–8.9) | 7.9 (7.1–8.7) | 8.4 (7.6–9.4) | 0.63 | 0.71 | 1 |
- aModels were adjusted for age (continuous), age at menarche (continuous), body fat % (continuous), race (non-Hispanic white, non-Hispanic black,
- other), family history of breast cancer (yes, no), oral contraceptive use (never, less than 1 year, 1–4 years, 5–9 years, more than 10 years),
- alcohol consumption (never, less than 1 drink per week, 1–2 drinks per week, 3–5 drinks per week, and 6 + drinks per week), parity/age at first birth (nulliparous, 1–2 children & < 25 years, 1–2 children & 25–29 years, 1–2 children &, ≥ 30 years, ≥ 3 children & < 25 years,
-  ≥ 3 children & ≥ 25 years) and body shape at age 10 (1&2, 3&4, 5, 6–9)
- bVolumetric percent density was log10 transformed and coefficients were back-transformed (10^β), and bolded if the Bonferroni p-trend is < 0.05
- cQuartile values: PC, Q1 = (1165 μM-1848 μM), Q2 = (> 1848 μM-2097 μM), Q3 = (> 2097 μM-2460 μM), Q4 = (> 2460 μM-4298 μM); LPC, Q1 = (60.1 μM-144 μM),
- Q2 = (> 144 μM-169 μM), Q3 = (> 169 μM-199 μM), Q4 = (> 199 μM-312 μM); PE, Q1 = (76.6-167 μM), Q2 = (> 167-195 μM), Q3 = (> 195-231 μM), Q4 = (> 231-471 μM);
- LPE, Q1 = (2.34–4.82 μM), Q2 = (> 4.82–5.84 μM), Q3 = (> 5.84–7.08 μM), Q4 = (> 7.08–12.04 μM); PI, Q1 = (2.68,-6.44 μM), Q2 = (> 6.44–7.75 μM),
- Q3 = (> 7.75–9.39 μM), Q4 = (> 9.39–18.77 μM); CER, Q1 = (3.04–5.58 μM), Q2 = (> 5.58–6.49 μM), Q3 = (> 6.49–7.43 μM), Q4 = (> 7.43–15.57 μM); DCER, Q1 = (0.879–1.66 μM), Q2 = (> 1.66–1.92 μM), Q3 = (> 1.92–2.25 μM), Q4 = (> 2.25–4.60 μM); HCER, Q1 = (1.78–3.38 μM), Q2 = (> 3.38–4.02 μM), Q3 = (> 4.02–4.67 μM), Q4 = (> 4.67–10.27 μM); LCER, Q1 = (1.47–2.92 μM), Q2 = (> 2.92–3.56 μM), Q3 = (> 3.56–4.29 μM), Q4 = (> 4.29–17.27 μM); SM, Q1 = (354-523 μM), Q2 = (> 523-586 μM), Q3 = (> 586-643 μM), Q4 = (> 643-1118 μM); CE, Q1 = (1066-1832 μM), Q2 = (> 1832-2062 μM), Q3 = (> 2062-2337 μM), Q4 = (> 2337-4335 μM); DAG, Q1 = (5.26–16.1 μM), Q2 = (> 16.1–22.1 μM), Q3 = (> 22.1–32.3 μM), Q4 = (> 32.3–106.8 μM); TAG, Q1 = (276-748 μM), Q2 = (> 748-1018 μM), Q3 = (> 1018-1516 μM), Q4 = (> 1516-6296 μM); MAG, Q1 = (0.23–0.79 μM), Q2 = (> 0.79–1.71 μM), Q3 = (> 1.71–12.89 μM), Q4 = (> 12.89–56.82 μM); Abbreviations: phosphatidylcholine (PC), lysophosphatidylcholine (LPC), phosphatidylethanolamine (PE), lysophosphatidylethanolamine (LPE),
- phosphatidylinositol (PI), ceramide (CER), dihydroceramide (DCER), hexosylceramide (HCER), lactosylceramide (LCER), sphingomyelin (SM),
- cholesteryl ester (CE), diacylglycerol (DAG), triacylglycerol (TAG), monoacylglycerol (MAG), quartiles 1–4 (Q1-4), least square mean (LSM),
- confidence interval (CI), false discovery rate (FDR)
