Table 2 Association of percentage change in quantitative imaging measures with pathologic response to NAC
Percentage change from baseline | Mid-treatment | Post-treatment | ||||
|---|---|---|---|---|---|---|
RCB 0/I N = 11a | RCB II/III N = 24b | p | RCB 0/I N = 11a | RCB II/III N = 20c | p | |
18F-FDG-PET | ||||||
 K1 | − 79.9 (14.6) | − 59.1 (46.2) | 0.12 | − 92 (12.6) | − 75.1 (26.7) | 0.01 |
 MRFDG | − 86.5 (19.1) | − 80.5 (40.7) | 0.40 | − 94.1 (13.2) | − 85.8 (23.3) | 0.11 |
 SUVmax (30–60 min) | − 72.8 (21.2) | − 59.0 (35.4) | 0.05 | − 76.3 (8.5) | − 64.1 (28.1) | 0.04 |
DW- and DCE-MRI | ||||||
 ADC | 22.2 (20.4) | 27.6 (40.0) | 0.72 | 47.5 (34.1) | 30.0 (52.9) | 0.55 |
 Peak PE | − 31.1 (12.6) | − 15.1 (28.0) | 0.03 | − 65.6 (19) | − 31.4 (55.9) | 0.02 |
 Peak SER | − 25.4 (21.9) | − 16.9 (27.1) | 0.13 | − 53.6 (8.6) | − 33.6 (24.5) | 0.01 |
 FTV | − 81.6 (16.4) | − 61.8 (32.8) | 0.11 | − 92.3 (7.8) | − 86.5 (27.9) | 0.16 |
 Washout volume | − 88.4 (8.5) | − 76.5 (21.4) | 0.09 | − 95.3 (5.0) | − 93.9 (17.3) | 0.18 |
 Longest dimension | − 34.6 (62.4) | − 25.9 (52.2) | 0.16 | − 100 (46.6) | − 39.4 (75.6) | 0.03 |
PET/MRI ratio | ||||||
 MRFDG/Peak PE | − 80.1 (27.6) | − 72.8 (42.6) | 0.50 | − 88.1 (41.7) | − 79.6 (54) | 0.46 |
 MRFDG/Peak SER | − 81.2 (25.5) | − 75.1 (40.7) | 0.48 | − 86.7 (27.2) | − 80.7 (45.4) | 0.41 |
MRFDG/K1 | − 34.2 (87.2) | − 56.0 (77.1) | 0.59 | − 49.3 (95.0) | − 33.0 (83.3) | 0.84 |
 SUVmax/Peak PE | − 57.7 (25.0) | − 44.0 (39.7) | 0.25 | − 32.6 (72.0) | − 33.6 (50.9) | 0.62 |
 SUVmax/Peak SER | − 61.9 (26.1) | − 48.3 (40.7) | 0.10 | − 49.4 (31.8) | − 37.1 (43.0) | 0.76 |