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Fig. 3 | Breast Cancer Research

Fig. 3

From: MiR-4649-5p acts as a tumor-suppressive microRNA in triple negative breast cancer by direct interaction with PIP5K1C, thereby potentiating growth-inhibitory effects of the AKT inhibitor capivasertib

Fig. 3

MiR-4649-5p reduces migration of TNBC cell lines. A The effect of transient miR-4649-5p mimic transfection on cell migration was assessed in a transwell migration assay. From each transwell, the number of cells in five representative fields of view (as seen in the representative pictures on the right) were counted and are presented as mean ± SD (n = 3; *p ≤ 0.05, **p ≤ 0.01). The impact of B transient and C stable miR-4649-5p overexpression on the migration of SUM159 cells was confirmed in scratch assays, where the closure of a scratch was observed for up to 45 h (as seen in the representative images on the right). At each time point the scratch areas relative to the 0 h time point were calculated and are presented as curves showing the progress of wound closure over time (n = 4; mean ± SD; **p ≤ 0.01, ***p ≤ 0.005)

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Breast Cancer Research

ISSN: 1465-542X

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