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Fig. 1 | Breast Cancer Research

Fig. 1

From: MiR-4649-5p acts as a tumor-suppressive microRNA in triple negative breast cancer by direct interaction with PIP5K1C, thereby potentiating growth-inhibitory effects of the AKT inhibitor capivasertib

Fig. 1

MiR-4649-5p is associated with better patient survival and shows low expression in triple negative breast cancer cell lines. A Kaplan Meier analysis showing overall survival of patients with TNBC split into a miR-4649-5p low (in black; n = 24) and high (in red; n = 73) expression group (log-rank test; p = 0.0079; Hazard Ratio (HR) = 0.26; confidence interval 0.09–0.76). B Digital droplet PCR showing endogenous miR-4649-5p expression in SUM159, MDA-MB-231, and BT-20 cells and transient miR-4649-5p mimic overexpression as positive controls. Droplet distributions including the threshold for positive droplets (top) and quantifications giving miR-4649-5p copies per μl (bottom) are shown (NTC…no-template control). C Digital droplet PCR showing endogenous expression and stable miR-4649-5p overexpression in SUM159 cells. Droplet distributions including the threshold for positive droplets (top) and quantifications giving the copies of miR-4649-5p per μl (bottom) are depicted (NTC…no-template control)

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Breast Cancer Research

ISSN: 1465-542X

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