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Fig. 4 | Breast Cancer Research

Fig. 4

From: The BET degrader ZBC260 suppresses stemness and tumorigenesis and promotes differentiation in triple-negative breast cancer by disrupting inflammatory signaling

Fig. 4

ZBC260 modulates the expression of stemness, BET protein-regulated, and EMT-MET genes. a Principal component analysis showing overall transcriptional changes in ALDH+ and ALDH− cell populations with and without ZBC260 treatment. b Stemness index of ALDH and ALDH-SUM159 cells with and without ZBC260 treatment. cVenn diagram depicting the number of significantly differentially expressed genes to ALDH+ and ALDH− cells population. d FDR Volcano plot of Top 20 significantly modulated genes in ALDH+ cells comparing treated to untreated cells. e–g Comparative expression of differentially expressed BET protein regulated genes, stemness genes, and EMT/MET genes in ALDH+ and ALDH− cells after ZBC260 treatment. The legend “NE” in fig. f and g means not expressed that is SOX-2,NANOG, CDH1,& EPCAM did not expressed in RNA seq data. FDR (P < 0.05) was considered significant. Statistics by Benjamini–Hochberg multiple comparisons test, n = 3 independent experiments

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Breast Cancer Research

ISSN: 1465-542X

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