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Fig. 1 | Breast Cancer Research

Fig. 1

From: Long non-coding RNA MIDEAS-AS1 inhibits growth and metastasis of triple-negative breast cancer via transcriptionally activating NCALD

Fig. 1

LncRNA MIDEAS-AS1 is downregulated in TNBC tissues and is associated with poor progression. A Heat map shows the significantly expressed lncRNAs in breast cancer samples compared to normal tissues from GEO (GSE60689) databases. The red shades represent high expression, and blue shades represent low expression. B Overlapping lowly expressed lncRNAs identified in GEO and TCGA lncRNA databases. C TCGA database showed that MIDEAS-AS1 was abnormally low expressed in breast cancer tissues. D The mRNA expression of MIDEAS-AS1 was lower in breast cancer tissues than in adjacent tissue. E qRT-PCR analysis of the expression of MIDEAS-AS1 in TNBC tissues and non-TNBC tissues. F qRT-PCR analysis of the relative expression of MIDEAS-AS1 in breast cancer organoids compared to the normal. G FISH analysis of the MIDEAS-AS1 in breast cancer and normal organoids. Scale bars, 20 μm. H Kaplan–Meier analysis showed the association between MIDEAS-AS1 expression and overall survival of TNBC patients. I Kaplan–Meier analysis showed the association between MIDEAS-AS1 expression and progression-free survival (PFS) of TNBC patients. Data were shown as mean ± SD. (*p < 0.05, ** p < 0.01, *** p < 0.001)

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Breast Cancer Research

ISSN: 1465-542X

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