Skip to main content

Table 1 Inhibitors of FOXM1

From: Targeting the oncogenic transcription factor FOXM1 to improve outcomes in all subtypes of breast cancer

Name

Mechanism

Cancers studied

References

p19ARF 26–44 peptide

Binds, localizes FOXM1 to nucleolus

Breast cancer, HCC, ALL

[38, 79, 80]

Thiozole antibiotics (thiostrepton, siomycin A)

Decrease FOXM1 level

Breast cancer, Ovarian cancer, ALL

[51, 74, 75, 93, 94]

FDI-6

Inhibits FOXM1 DNA binding

Breast cancer

[77]

NB55, NB73, NB115

Bind FOXM1, decrease FOXM1 level

Breast cancer, Ovarian cancer, Multiple myeloma, Melanoma

[28, 53, 59, 64, 65, 75, 81, 91]

STL 427944

Relocates FOXM1 to cytoplasm

Various cancer cells

[82]

DZY-4

Inhibits FOXM1 DNA binding

Ovarian cancer

[83]

FOXM1 PROTACS

Degrade FOXM1

Breast cancer, Liver cancer, Ovarian cancer

[78, 84]

  1. ALL—acute lymphoblastic leukemia, HCC—hepatocellular carcinoma