Fig. 1

FOXM1 protein domains and phosphorylation sites. Schematic showing the domain structure of human FOXM1c (763 amino acids), its phosphorylation sites and the protein kinases involved. Phosphorylation of FOXM1 activates FOXM1 nuclear translocation and transcriptional activity, and is crucial to relieve autorepression by the N-terminal Repressor Domain (NRD). See text for further details. NRD N-terminal Repressor Domain, DBD DNA binding (forkhead) domain, TAD Transactivation Domain