MRI-based breast cancer radiogenomics using RNA profiling: association with subtypes in a single-center prospective study

Table 4 Enriched functional annotation of the differentially expressed genes according to lesion type in ER-positive Cancer

Functional annotation	P value	Genes
Cell division of breast cancer cell lines	0.018	IGF1
Migration of breast cancer cell lines	0.022	DPP4,IGF1,SLC16A4,WNT11
Transition of breast cancer cell lines	0.023	IGF1
Arrest in G0/G1 phase transition of breast cancer cell lines	0.032	IGF1
Breast or gastric cancer	0.035	ACACB,ADRA1D,CRHBP,DPP4,DYRK2,FER1L5,HMX1,IFNA10,IGF1,IL1RL1,LARP7,MAP6,SCN3A,SCN7A,SCUBE2,SLC16A4,WNT11
Breast or gynecological cancer	0.037	ACACB,ADRA1D,CRHBP,DPP4,DYRK2,FER1L5,IGF1,IL18R1,IL1RL1,LARP7,MAP6,RCVRN,SCN3A,SCN7A,SCUBE2,SLC16A4,WNT11,ZNF136
Breast or ovarian carcinoma	0.037	ACACB,ADRA1D,CRHBP,DPP4,FER1L5,IGF1,IL1RL1,MAP6,SCN3A,SCN7A,SCUBE2,WNT11
Anoikis of breast cell lines	0.038	IGF1
Mitogenesis of breast cancer cell lines	0.041	IGF1
Entry into S phase of breast cancer cell lines	0.046	IGF1
Chemotaxis of breast cancer cell lines	0.047	IGF1

Enriched functional annotations were obtained from Ingenuity Pathway Analysis (Ingenuity Systems, Redwood City, Calif) with an input of differentially expressed genes according to MRI phenotype (Q < 0.1) and the functions associated with breast cancer or general cancer were annotated

ISSN: 1465-542X