Fig. 4

Radiogenomic correlations according to SD on PrecontrastT1 at SSF5 in 15 participants with TNBC. A A heat map image demonstrates 536 differentially expressed genes according to the lesion type (P < 0.05 and log2FC > 2.0 or < − 2.0). Columns represent 536 individual differentially expressed genes (Ensemble Gene ID). The color key indicates the degree of differential gene expression in either direction to upregulation (red) or downregulation (blue). The MRI image and histogram framed in yellow shows breast cancer with increased SD on PrecontrastT1 at SSF5 (81.9, > mean value 63.9) in a 48-year-old woman. The MRI image and histogram framed in green shows breast cancer with decreased SD on PrecontrastT1 at SSF5 (43.7, ≤ mean value 63.9) in a 50-year-old woman. B A volcano plot demonstrates the differentially expressed genes in breast cancers with increased SD on PrecontrastT1 at SSF5 compared with those with decreased SD on PrecontrastT1 at SSF5 (Q < 0.1). The x-axis represents the degree of differential gene expression (log2FC) of individual genes, and the y-axis represents the negative logarithm of their Q value to base 10. Positive log2FC values represent upregulation in cancers with mass type compared with those with non-mass enhancement, and negative values represent downregulation. Green circles represent differentially expressed genes between cancers with increased SD on PrecontrastT1 at SSF5 and cancers with decreased SD on PrecontrastT1 at SSF5 with Q < 0.1 and log2FC > 2.0 or < − 2.0