Fig. 3

Radiogenomic correlations according to the lesion type in 65 participants with ER-positive breast cancer. A A heat map image demonstrates 320 differentially expressed genes according to the lesion type (P < 0.05 and log2FC > 2.0 or < − 2.0). Columns represent 320 individual differentially expressed genes (Ensemble Gene ID). The color key indicates the degree of differential gene expression in either direction to upregulation (red) or downregulation (blue). A MRI image framed in yellow shows breast cancer with mass type in a 36-year-old woman. The mass shows irregular shape, irregular margin, and heterogeneous enhancement. A MRI image framed in green shows breast cancer with non-mass enhancement type in a 52-year-old woman. This lesion shows focal homogenous non-mass enhancement. B A volcano plot demonstrates the differentially expressed genes in breast cancers with mass type compared with those with non-mass enhancement (Q < 0.1). The x-axis represents the degree of differential gene expression (log2FC) of individual genes, and the y-axis represents the negative logarithm of their Q value to base 10. Positive log2FC values represent upregulation in cancers with mass type compared with those with non-mass enhancement, and negative values represent downregulation. Green circles represent differentially expressed genes between cancers with lesion type mass and cancers with non-mass enhancement with Q < 0.1 and log2FC > 2.0 or < − 2.0