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Table 1 Relative risk (95% CI) of breast cancer, observed in a Danish cohort of women aged 15–49 years and without a history of cancer, venous thromboembolism or fertility treatment [64]

From: Progesterone from ovulatory menstrual cycles is an important cause of breast cancer

(a) Relative risk according to time since use and duration of any type of hormonal contraception

Duration of use

Relative risk of breast cancer (95% CI)

 < 1 yr since recent use

1 to < 5 yr since recent use

5–10 yr since recent use

 < 1 yr

0.96 (0.78–1.19)

0.96 (0.85–1.09)

1.01 (0.88–1.15)

1 to < 5 yr

1.04 (0.88–1.23)

1.06 (0.96–1.18)

1.07 (0.94–1.20)

5–10 yr

1.33 (1.11–1.59)

1.16 (1.02–1.33)

1.30 (1.06–1.58)

 > 10 yr

1.52 (1.17–1.98)

1.16 (0.89–1.49)

NA

(b) Relative risk among women using current or recent P-only contraception

Current or recent P-only contraception

Relative risk (95% CI)

Oral contraception

NETA

1.00 (0.80–1.25)

LNG

1.93 (1.18–3.16)

DSG

1.18 (0.87–1.60)

Intra-uterine device

LNG

1.21 (1.11–1.33)

  1. Reference group: women who had never used hormonal contraception; Recent: defined as discontinuation of hormonal contraception within the previous 6 months; NA: not applicable due to too small number of events
  2. CI confidence interval, DSG desogestrel, LNG levonorgestrel, NETA norethisterone acetate, yr year