Fig. 5
From: S100A6 inhibits MDM2 to suppress breast cancer growth and enhance sensitivity to chemotherapy
Effects of S100A6 on the growth, apoptosis, and cell cycle of breast cancer cells. A Clonogenic assay of MCF-7 cells transfected with S100A6, MDM2, or MDM2 and S100A6 with or without paclitaxel. B WST-1 results of MCF-7 transfected with S100A6, MDM2, or MDM2 and S100A6, and those of the cells after 24 h of paclitaxel treatment. C and D Cell apoptosis and cell-cycle results of MCF-7 cells transfected with S100A6, MDM2, or MDM2 and S100A6, and those of the cancer cells treated with 100 μM paclitaxel for different times, respectively. Data were shown as mean ± SD; n = 3 independent experiments. *P < 0.05, **P < 0.01, and ***P < 0.001